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Index > Protein center > Csk(Gene name) > Mouse
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  • Csk (Gene name),
  • Tyrosine-protein kinase CSK (Protein name ),  CSK_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Csk;
    Protein name:
    Tyrosine-protein kinase CSK;
    Alternative:
    Protein-tyrosine kinase MPK-2;C-Src kinase;p50CSK;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with phosphorylated SIT1 and LIME1. Interacts with SRCIN1 (By similarity). Interacts with PTPN8. Interacts with phosphorylated PAG1 and TGFB1I1.
    Function:
    Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.
    Subcellular Location:
    Cytoplasm Cell membrane Mainly cytoplasmic, also present in lipid rafts.
    Protein Attributes:
    Sequence length:
    450
    Sequence:
    50:
    MSAIQAAWPS | GTECIAKYNF | HGTAEQDLPF | CKGDVLTIVA | VTKDPNWYKA | 
    100:
    KNKVGREGII | PANYVQKREG | VKAGTKLSLM | PWFHGKITRE | QAERLLYPPE | 
    150:
    TGLFLVREST | NYPGDYTLCV | SCEGKVEHYR | IMYHASKLSI | DEEVYFENLM | 
    200:
    QLVEHYTTDA | DGLCTRLIKP | KVMEGTVAAQ | DEFYRSGWAL | NMKELKLLQT | 
    250:
    IGKGEFGDVM | LGDYRGNKVA | VKCIKNDATA | QAFLAEASVM | TQLRHSNLVQ | 
    300:
    LLGVIVEEKG | GLYIVTEYMA | KGSLVDYLRS | RGRSVLGGDC | LLKFSLDVCE | 
    350:
    AMEYLEGNNF | VHRDLAARNV | LVSEDNVAKV | SDFGLTKEAS | STQDTGKLPV | 
    400:
    KWTAPEALRE | KKFSTKSDVW | SFGILLWEIY | SFGRVPYPRI | PLKDVVPRVE | 
    450:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Tyrosine-protein kinase CSK
    Cat.:
    E11982h
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    Packing:
    96T
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    ELISA Kit for Mouse Tyrosine-protein kinase CSK
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse Tyrosine-protein kinase CSK
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse Tyrosine-protein kinase CSK
    Cat.:
    E11982m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Tyrosine-protein kinase CSK
    Cat.:
    E11982r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Tyrosine-protein kinase CSK
    Cat.:
    U11982m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Tyrosine-protein kinase CSK
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Tyrosine-protein kinase CSK
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Tyrosine-protein kinase CSK
    Cat.:
    U11982h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Tyrosine-protein kinase CSK
    Cat.:
    U11982r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Tyrosine-protein kinase CSK
    Cat.:
    P11982Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tyrosine-protein kinase CSK
    Polyclonal Antibody for Mouse Tyrosine-protein kinase CSK
    Polyclonal Antibody for Mouse Tyrosine-protein kinase CSK
    Polyclonal Antibody for Mouse Tyrosine-protein kinase CSK
    Monoclonal Antibody for Mouse Tyrosine-protein kinase CSK
    Monoclonal Antibody for Mouse Tyrosine-protein kinase CSK
    Monoclonal Antibody for Mouse Tyrosine-protein kinase CSK
    Monoclonal Antibody for Mouse Tyrosine-protein kinase CSK
    Monoclonal Antibody for Mouse Tyrosine-protein kinase CSK
    Protein for Mouse Tyrosine-protein kinase CSK
    Protein for Mouse Tyrosine-protein kinase CSK
    Protein for Mouse Tyrosine-protein kinase CSK
    Protein for Mouse Tyrosine-protein kinase CSK
    Protein for Mouse Tyrosine-protein kinase CSK

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family."
      Klages S. , Adam D. , Class K. , Fargnoli J. , Bolen J.B. , Penhallow R.C.
      Proc. Natl. Acad. Sci. U.S.A.91:2597-2601(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    2. 2.
      "Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains."
      Farber C.R. , Corva P.M. , Medrano J.F.
      Submitted (2005-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: CAST/Ei.
      tissue: Brain.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NOD.
      tissue: Spleen.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Brain.
      tissue: Colon.
    5. 5.
      "An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain."
      Gilardi-Hebenstreit P. , Nieto M.A. , Frain M. , Mattei M.-G. , Chestier A. , Wilkinson D.G. , Charnay P.
      Oncogene7:2499-2506(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 316-367
      strain: C57BL/6.
      tissue: Embryonic brain.
    6. 6.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 338-347;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
    7. 7.
      "Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice."
      Imamoto A. , Soriano P.
      Cell73:1117-1124(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    8. 8.
      "Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells."
      Cloutier J.-F. , Veillette A.
      EMBO J.15:4909-4918(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN8
    9. 9.
      "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin."
      Thomas S.M. , Hagel M. , Turner C.E.
      J. Cell Sci.112:181-190(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
    10. 10.
      "Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells."
      Yasuda K. , Nagafuku M. , Shima T. , Okada M. , Yagi T. , Yamada T. , Minaki Y. , Kato A. , Tani-Ichi S. , Hamaoka T. , Kosugi A.
      J. Immunol.169:2813-2817(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PAG1
    11. 11.
      "Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor."
      Davidson D. , Bakinowski M. , Thomas M.L. , Horejsi V. , Veillette A.
      Mol. Cell. Biol.23:2017-2028(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PAG1
    12. 12.
      "Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development."
      Xu S. , Huo J. , Tan J.E.-L. , Lam K.-P.
      Mol. Cell. Biol.25:8486-8495(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PAG1;SUBCELLULAR LOCATION
    13. 13.
      "A novel, specific interaction involving the Csk SH3 domain and its natural ligand."
      Ghose R. , Shekhtman A. , Goger M.J. , Ji H. , Cowburn D.
      Nat. Struct. Biol.8:998-1004(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-83
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